Date Field | Doc. No. | Party | Description |
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Nov 27, 2018 | 53 | | Termination Decision Document Download |
Nov 27, 2018 | 51 | | Joint Request to File Settlement Confidential Download |
Nov 27, 2018 | 52 | | Decision - 37 C.F.R. 42.74 Download |
Nov 27, 2018 | 50 | | Joint Motion to Terminate Download |
Sep 27, 2018 | 49 | | Hearing Transcript Download |
Aug 31, 2018 | 47 | | Petitioners' Objections to Patent Owners' Demonstratives Download |
Aug 31, 2018 | 48 | | Patent Owner's Objections to Petitioner's Demonstratives Download |
Aug 31, 2018 | 2065 | | Patent Owner's Demonstrative Exhibits Download |
Aug 31, 2018 | 1065 | | Petitioners' Demonstrative Exhibits Oral Argument Download |
Aug 21, 2018 | 44 | | Petitioners' Reply in Support of Their Motion to Exclude Evidence Download |
Aug 21, 2018 | 45 | | Patent Owners' Reply In Further Support of Their Motion to Exclude Download |
Aug 21, 2018 | 46 | | Order - Trial Hearing Download |
Aug 13, 2018 | 43 | | ORDER Conduct of the Proceeding Download |
Aug 9, 2018 | 41 | | Petitioners¿¿¿ Opposition to Patent Owners¿¿¿ Motion to Exclude Download |
Aug 9, 2018 | 42 | | Petitioners¿¿¿ Updated Exhibit List Download |
Aug 9, 2018 | 40 | | Petitioners¿¿¿ Response to Patent Owners¿¿¿ Motion for Observation Regarding Cross-Examination of Petitioners¿¿¿ Expert, Dr. Aron D. Rose Download |
Aug 9, 2018 | 2053 | | Ex. 2053 - Tafluprost PMDA Entry Download |
Aug 9, 2018 | 38 | | Patent Owner's Third Updated Exhibit List Download |
Aug 9, 2018 | 2055 | | Ex. 2055 - Tapros Package Insert Download |
Aug 9, 2018 | 39 | | Petitioners¿¿¿ Response to Patent Owners¿¿¿ Motion for Observation Regarding Cross-Examination of Petitioners¿¿¿ Expert, Dr. Mitchell A. deLong Download |
Aug 9, 2018 | 2052 | | Ex. 2052 - CA Federal Court link to Alcon Canada v. Apotex Download |
Aug 9, 2018 | 2054 | | Ex. 2054 - Tapros Drug Information Sheet Download |
Aug 9, 2018 | 37 | | Patent Owners' Opposition to Petitioners' Motion to Exclude Download |
Aug 9, 2018 | 2051 | | Ex. 2051 - WestLaw Version of Alcon Canada v. Apotex Download |
Aug 9, 2018 | 1063 | | Exhibit 1063 - Kubinyi1979 - Progress in Drug research 23 97 (1979) Download |
Aug 9, 2018 | 1064 | | Exhibit 1064 - Primary care optometry news. - NLM Catalog - NCBI Download |
Jul 26, 2018 | 2063 | | Ex. 2063 - Human Metabolome Database - tafluprost (replacement for Ex. 2056) Download |
Jul 26, 2018 | 35 | | Patent Owners' Motion for Observation - Rose Download |
Jul 26, 2018 | 30 | | Petitioners' Motion to Exclude Evidence Download |
Jul 26, 2018 | 2056 | | Ex. 2056 - Human Metabolome Database - tafluprost Download |
Jul 26, 2018 | 2058 | | Ex. 2058 - Rulo 1994 Download |
Jul 26, 2018 | 2064 | | Ex. 2064 - Human Metabolome Database - latanoprost (replacement for Ex. 2057) Download |
Jul 26, 2018 | 2059 | | Ex. 2059 - Villumsen and Alm 1992 Download |
Jul 26, 2018 | 2061 | | Ex. 2061 - deLong Transcript II Download |
Jul 26, 2018 | 2062 | | Ex. 2062 - Rose Transcript II Download |
Jul 26, 2018 | 2057 | | Ex. 2057 - Human Metabolome Database - latanoprost Download |
Jul 26, 2018 | 2060 | | Ex. 2060 - Xalatan label, Nov. 26, 2001 Download |
Jul 26, 2018 | 34 | | Patent Owners' Motion for Observation - deLong Download |
Jul 26, 2018 | 32 | | Patent Owners' Motion to Exclude Download |
Jul 26, 2018 | 33 | | Patent Owners' Request for Oral Argument Download |
Jul 26, 2018 | 31 | | Petitioners' Request for Oral Argument Download |
Jul 26, 2018 | 36 | | Patent Owner's Second Updated Exhibit List Download |
Jun 22, 2018 | 29 | | Patent Owners' Notice of Deposition - Rose Download |
Jun 22, 2018 | 28 | | Patent Owners' Notice of Deposition - deLong Download |
Jun 12, 2018 | 27 | | Patent Owners' Objections to Evidence Download |
Jun 5, 2018 | 26 | | Petitioners' Updated Exhibit List Download |
Jun 5, 2018 | 24 | | Petitioners' Reply to Patent Owner Brief Download |
Jun 5, 2018 | 25 | | Petitioners' Updated Exhibit List Download |
Jun 5, 2018 | 1038 | | Mishima, Hiromu K., et al., ¿¿¿Circadian Intraocular Pressure Management with Latanoprost: Diurnal and Nocturnal Intraocular Pressure Reduction and Increased Uveoscleral Outflow,¿¿¿ Survey of Ophthalmology, vol. 41:2 (Feb. 1997). Download |
Jun 5, 2018 | 1046 | | Husain S. et al., ¿¿¿Latanoprost-Induced Changes in Rat Intraocular
Pressure: Direct or Indirect ?¿¿¿ J. Ocul. Pharmacol. Ther., 24(4):367¿¿¿372 (2008). Download |
Jun 5, 2018 | 1036 | | Alm A., ¿¿¿Latanoprost in the treatment of glaucoma,¿¿¿ Clin. Ophthalmol., 8:1967¿¿¿85 (2014). Download |
Jun 5, 2018 | 1043 | | Fogagnolo, Paolo et al. ¿¿¿A 1-Year Randomized Study of the Clinical and Confocal Effects of Tafluprost and Latanoprost in Newly Diagnosed Glaucoma Patients,¿¿¿ Adv. Ther., 32:356¿¿¿369 (2015). Download |
Jun 5, 2018 | 1037 | | Alan Robin, MD, ¿¿¿Two new options will make glaucoma therapy safer,¿¿¿ Primary Care Optometry News, July 1996. Download |
Jun 5, 2018 | 1048 | | Skuballa W. et al., ¿¿¿15, 15-Ketals of Natural
Prostaglandins and Prostaglandin Analogues. Synthesis and Biological Activities,¿¿¿ J. Med. Chem. 21:443¿¿¿447 (1978). Download |
Jun 5, 2018 | 1041 | | Konstas, Anatasios G P et al. ¿¿¿Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension,¿¿¿ Br. J. Opthalmol. 97:1510¿¿¿1515 (2013). Download |
Jun 5, 2018 | 1035 | | U.S. Patent No. 5,296,504 to Stjernschantz et al., issued March 22, 1994. Download |
Jun 5, 2018 | 1059 | | Exhibit 1059 - Santen Pharmaceutical Co., Ltd. Data Book (2017) Download |
Jun 5, 2018 | 1054 | | Santen Pharmaceutical Co., Ltd. Data Book Year Ended March 31, 2016. Download |
Jun 5, 2018 | 1045 | | Patel S.S. et al., ¿¿¿Latanoprost: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability in the Management of Primary Open-Angle. Glaucoma and Ocular Hypertension,¿¿¿ Drugs Aging, 9(5):363¿¿¿78 (November 1996). Download |
Jun 5, 2018 | 1049 | | Bito L.Z., ¿¿¿Comparison of the Ocular Hypotensive Efficacy of Eicosanoids and Related Compounds,¿¿¿ Exp. Eye Res., 38(2):181¿¿¿94 (1984). Download |
Jun 5, 2018 | 1056 | | Exhibit 1056 - Aerie Pharmaceuticals, Inc. Form 8-K (2018) Download |
Jun 5, 2018 | 1047 | | Resul B. et al., ¿¿¿Phenyl-Substituted Prostaglandins: Potent and Selective Antiglaucoma Agents,¿¿¿ J. Med. Chem., 36:243¿¿¿248 (1993). Download |
Jun 5, 2018 | 1042 | | Ikeda, Yoko et al. ¿¿¿Comparison study of intraocular pressure reduction efficacy and safety between latanoprost and tafluprost in Japanese with normal-tension glaucoma,¿¿¿ Clinical Ophthalmology, 10:1633¿¿¿1637 (2016). Download |
Jun 5, 2018 | 1055 | | Exhibit 1055 - GlobalData Healthcare (2018) Download |
Jun 5, 2018 | 1040 | | Camras C.B. et al., ¿¿¿Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma: a six-month, masked, multicenter trial in the United States,¿¿¿ Ophthalmology, 103(1):138¿¿¿47 (January 1996). Download |
Jun 5, 2018 | 1062 | | Exhibit 1062 - Appendix B to Exhibit 1032 Download |
Jun 5, 2018 | 1061 | | Exhibit 1061 - U.S. Patent No. 4,599,353 to Bito L.Z. (1986) Download |
Jun 5, 2018 | 1032 | | Supplemental Declaration of Aron D. Rose, M.D. Download |
Jun 5, 2018 | 1031 | | Supplemental Declaration of Mitchell A. deLong, Ph.D. Download |
Jun 5, 2018 | 1052 | | Latanoprost DrugBank Profile, available at https://www.drugbank.ca/drugs/DB00654 (last visited May 31, 2018). Download |
Jun 5, 2018 | 1033 | | Kerstetter, J.R. et al., ¿¿¿Prostaglandin F2¿¿-1-Isopropylester Lowers Intraocular Pressure Without Decreasing Aqueous Humor Flow,¿¿¿ American Journal of Ophthalmology, Vol. 105, No. 1, 30¿¿¿34 (1988). Download |
Jun 5, 2018 | 1060 | | Exhibit 1060 - Santen Pharmaceutical Co., Ltd. Annual Report (2014) Download |
Jun 5, 2018 | 1039 | | Camras et al., ¿¿¿Latanoprost, a Prostaglandin Analog, for Glaucoma Therapy: efficacy and safety after 1 year of treatment in 198 patients,¿¿¿ Ophthalmology, 103:1916¿¿¿1924 (November 1996). Download |
Jun 5, 2018 | 1051 | | deLong M.A., ¿¿¿Seminar on Lipophilicity including
a method for estimating the logP of organic compounds,¿¿¿ Lecture notes follow circa 1989, Stanford University. Download |
Jun 5, 2018 | 1058 | | Santen Pharmaceutical Co., Ltd. Data Book (2015) Download |
Jun 5, 2018 | 1050 | | Judith A.K. Howard et al., ¿¿¿How Good is Fluorine as a
Hydrogen Bond Acceptor?¿¿¿ Tetrahedron, 52:12613¿¿¿12622 (Sept. 1996). Download |
Jun 5, 2018 | 1034 | | Villumsen, Jorgen et al., ¿¿¿Prostaglandin F2¿¿-isopropylester eye drops: effect on intraocular pressure in open-angle glaucoma,¿¿¿ Br. J. Opthalmol. 73:975¿¿¿979 (1989). Download |
Jun 5, 2018 | 1057 | | Exhibit 1057 - Aerie Pharmaceuticals, Inc. Form 8-K (2017) Download |
Jun 5, 2018 | 1053 | | Santen Pharmaceutical Co., Ltd. Annual Report 2013 Download |
Jun 5, 2018 | 1044 | | Lee P-Y et al., ¿¿¿Effect of prostaglandin F2¿¿ on aqueous humor dynamics of rabbit, cat, and monkey,¿¿¿ Invest Ophthalmol Vis Sci, 25:1087¿¿¿1093 (1984). Download |
Mar 12, 2018 | 23 | | Petitioners' Objections to Evidence Download |
Mar 5, 2018 | 2024 | | Ex.2024 - Lee 1985 Download |
Mar 5, 2018 | 2032 | | Ex.2032 - Zioptan Label Download |
Mar 5, 2018 | 2033 | | Ex.2033 - Ueno Japan (PO Translation) Download |
Mar 5, 2018 | 2044 | | Ex.2044 - Tapros Medication Guide Download |
Mar 5, 2018 | 2045 | | Ex.2045 - Micro Labs Complaint Download |
Mar 5, 2018 | 2025 | | Ex.2025 - deLong Transcript Download |
Mar 5, 2018 | 2046 | | Ex.2046 - Sandoz Complaint Download |
Mar 5, 2018 | 2028 | | Ex.2028 - Supplemental Macdonald Declaration Download |
Mar 5, 2018 | 2031 | | Ex.2031 - Takagi 2004 Download |
Mar 5, 2018 | 2039 | | Ex.2039 - Lumigan 0.01 Label Download |
Mar 5, 2018 | 2043 | | Ex.2043 - Iopidine Label Download |
Mar 5, 2018 | 2037 | | Ex.2037 - Xalatan Label Download |
Mar 5, 2018 | 2027 | | Ex.2027 - CA Public Judgment and Reasons Download |
Mar 5, 2018 | 2041 | | Ex.2041 - Travatan Z Label Download |
Mar 5, 2018 | 22 | | Patent Owner Response Download |
Mar 5, 2018 | 2038 | | Ex.2038 - Lumigan 0.03 Label Download |
Mar 5, 2018 | 2040 | | Ex.2040 - Travatan Label Download |
Mar 5, 2018 | 2042 | | Ex.2042 - Rescula Label Download |
Mar 5, 2018 | 2029 | | Ex.2029 - Supplemental Fechtner Declaration Download |
Mar 5, 2018 | 2034 | | Ex.2034 - Wang 1998 Download |
Mar 5, 2018 | 2030 | | Ex.2030 - Santen Financial Results Download |
Mar 5, 2018 | 2035 | | Ex.2035 - Aung 2001 Download |
Mar 5, 2018 | 2036 | | Ex.2036 - Aung 2002 Download |
Mar 5, 2018 | 2026 | | Ex.2026 - Rose Transcript Download |
Mar 5, 2018 | 2047 | | Ex.2047 - Dunitz 1997 Download |
Mar 5, 2018 | 2048 | | Ex.2048 - Carey 1984 Download |
Mar 5, 2018 | 2023 | | Ex.2023 - USP 5977173 Download |
Feb 6, 2018 | 21 | | Petitioners' Updated Mandatory Notices Download |
Feb 5, 2018 | 20 | | Granting Petitioner's Motion for Admission Pro Hac Vice of H. Keeto Sabharwal Download |
Jan 22, 2018 | 18 | | Patent Owners' Notice of Deposition - deLong Download |
Jan 22, 2018 | 19 | | Patent Owners' Notice of Deposition - Rose Download |
Jan 3, 2018 | 17 | | MOTION FOR PRO HAC VICE ADMISSION OF H. KEETO SABHARWAL UNDER 37 C.F.R. ¿¿ 42.10(c) Download |
Dec 18, 2017 | 16 | | IPR2017-01434 Patent Owners' Objections to Evidence Download |
Dec 13, 2017 | 15 | | IPR2017-01434 Patent Owners' Objections to Evidence Download |
Dec 11, 2017 | 14 | | Petitioners' Updated Exhibit List Download |
Dec 11, 2017 | 1030 | | Exhibit 1030 - New Version of Exhibit 1007 with Certified Translation Download |
Dec 11, 2017 | 1029 | | Exhibit 1029 - New Version of Exhibit 1006 with Certified Translation Download |
Dec 6, 2017 | 13 | | Order Patent Owner's Amended Motion for Admission
Pro Hac Vice of Eric J. Lobenfeld, Esq. Download |
Nov 29, 2017 | 11 | | Trial Instituted Document Download |
Nov 29, 2017 | 12 | | Scheduling Order Download |
Sep 7, 2017 | 9 | | Patent Owners' Updated Mandatory Notices Download |
Sep 7, 2017 | 2009 | | Ex. 2009 - Stjernschantz 1996 Download |
Sep 7, 2017 | 2020 | | Ex. 2020 - Schoenwald 1978 Download |
Sep 7, 2017 | 2010 | | Ex. 2010 - Collins 1993 Download |
Sep 7, 2017 | 2012 | | Ex. 2012 - Bito 1987 Download |
Sep 7, 2017 | 2001 | | Ex. 2001 - Macdonald Declaration Download |
Sep 7, 2017 | 2017 | | Ex. 2017 - EP0364417A1 Download |
Sep 7, 2017 | 2019 | | Ex. 2019 - R-Tech Ueno 2009 Download |
Sep 7, 2017 | 2007 | | Ex. 2007 - Coleman 1994 Download |
Sep 7, 2017 | 2003 | | Ex. 2003 - Camras 1977 Download |
Sep 7, 2017 | 2018 | | Ex. 2018 - Qiu 2015 Download |
Sep 7, 2017 | 2002 | | Ex. 2002 - Fechtner Declaration Download |
Sep 7, 2017 | 2013 | | Ex. 2013 - Villumsen 1989 Download |
Sep 7, 2017 | 2021 | | Ex. 2021 - Klimko 2004 Download |
Sep 7, 2017 | 2016 | | Ex. 2016 - Camras 1996 Download |
Sep 7, 2017 | 2005 | | Ex. 2005 - Fung 2014 Download |
Sep 7, 2017 | 2004 | | Ex. 2004 - Xalatan 1996 Download |
Sep 7, 2017 | 2014 | | Ex. 2014 - Villumsen 1990 Download |
Sep 7, 2017 | 2015 | | Ex. 2015 - Camras 1997 Download |
Sep 7, 2017 | 2008 | | Ex. 2008 - Konturek 1986 Download |
Sep 7, 2017 | 2006 | | Ex. 2006 - Linden 1999 Download |
Sep 7, 2017 | 2011 | | Ex. 2011 - Giuffre 1985 Download |
Sep 7, 2017 | 2022 | | Ex. 2022 - WO1995026729A1 Download |
Sep 7, 2017 | 10 | | Patent Owner Preliminary Response Download |
Jun 14, 2017 | 8 | | Amended Motion for Pro Hac Vice Admission of Eric J. Lobenfeld Download |
Jun 12, 2017 | 7 | | Motion for Pro Hac Vice Admission of Eric J. Lobenfeld Download |
Jun 8, 2017 | 6 | | Notice of Accord Filing Date Download |
Jun 1, 2017 | 3 | | Patent Owners' Mandatory Notices Download |
Jun 1, 2017 | 4 | | Power of Attorney - Santen Download |
Jun 1, 2017 | 5 | | Power of Attorney - AGC Download |
May 12, 2017 | 1007 | | Exhibit 1007 - Bezuglov, V. V. & L. D. Bergelson, ¿¿¿Fluoroprostaglandins¿¿¿A New Class of Biologically Active Analogues of Natural Prostaglandins Download |
May 12, 2017 | 1005 | | Exhibit 1005 - U.S. Patent No. 5,292,754 to Kishi et al. Download |
May 12, 2017 | 1017 | | Exhibit 1017 - Patent and Exclusivity for: N202514 (ZIOPTAN) Download |
May 12, 2017 | 1024 | | Exhibit 1024 - Bito Download |
May 12, 2017 | 1010 | | Exhibit 1010 - Stjernschantz, J.W. ¿¿¿From PGF2-Isopropyl Ester to Latanoprost: A Review of the Development of Xalatan Download |
May 12, 2017 | 1014 | | Exhibit 1014 - Alm A 1989 Progress in Clin and Biological Research Download |
May 12, 2017 | 1006 | | Exhibit 1006 - JP-A-7070054 to Ueno Japan et al. Download |
May 12, 2017 | 1027 | | Exhibit 1027 - Declaration of Mitchell deLong, Ph.D. Download |
May 12, 2017 | 1009 | | Exhibit 1009 - Camras et al. Reduction of intraocular pressure in normal and glaucomatous primate (Aotus trivirgatus) Download |
May 12, 2017 | 1020 | | Exhibit 1020 - Nilsson, S.F. et al., ¿¿¿Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2 alpha-1-isopropylester in the cynomolgus monkey Download |
May 12, 2017 | 1011 | | Exhibit 1011 - Nixon, D. ¿¿¿Hyperemia in Glaucoma Patients Download |
May 12, 2017 | 1026 | | Exhibit 1026 - Nelson, N.A. ¿¿¿Prostaglandin Nomenclature Download |
May 12, 2017 | 1018 | | Exhibit 1018 - Lee, P.Y. et al., ¿¿¿The effect of prostaglandin F2 alpha on intraocular pressure in normotensive human subjects Download |
May 12, 2017 | 1013 | | Exhibit 1013 - U.S. Provisional Patent Application No. 60/030,519 to Klimko et al. Download |
May 12, 2017 | 1023 | | Exhibit 1023 - Lee, P.Y. et al., ¿¿¿Pharmacological testing in the laser-induced monkey glaucoma model Download |
May 12, 2017 | 1004 | | Exhibit 1004 - EP0471856A1 to Kishi et al. Download |
May 12, 2017 | 1019 | | Exhibit 1019 - Camras, C.B. et al., ¿¿¿Maintained reduction of intraocular pressure by prostaglandin F2 alpha-1-isopropyl ester applied in multiple doses in ocular hypertensive and glaucoma patients Download |
May 12, 2017 | 1002 | | Exhibit 1002 - File History of U.S. Patent No. 5,886,035 to Shirasawa et al. Download |
May 12, 2017 | 1022 | | Exhibit 1022 - Radius, R.L. et al., ¿¿¿Laser-induced primate glaucoma. II. Histopathology Download |
May 12, 2017 | 1003 | | Exhibit 1003 - EP0639563A2 to Klimko et al. Download |
May 12, 2017 | 2 | | Power of Attorney Download |
May 12, 2017 | 1021 | | Exhibit 1021 - Pederson, J.E. et al., ¿¿¿Laser-induced primate glaucoma Download |
May 12, 2017 | 1012 | | Exhibit 1012 - PCT/US97/20671 to Klimko et al. Download |
May 12, 2017 | 1015 | | Exhibit 1015 - Stjernschantz J 1992 Drugs of the Future Download |
May 12, 2017 | 1008 | | Exhibit 1008 - Bezuglov, Vladimir V. ¿¿¿Fluorodeoxy Prostaglandins, Synthesis and Perspectives Download |
May 12, 2017 | 1025 | | Exhibit 1025 - U.S. Patent No. 3,914,265 to Middleton Download |
May 12, 2017 | 1 | | Petition for Inter Partes Review of U.S. Patent No. 5,886,035. Download |
May 12, 2017 | 1028 | | Exhibit 1028 - Declaration of Aron D. Rose, M.D. Download |
May 12, 2017 | 1016 | | Exhibit 1016 -Product Details for NDA 020597 (XALATAN) Download |
May 12, 2017 | 1001 | | Exhibit 1001 - U.S. Patent No. 5,886,035 to Shirasawa et al. Download |