Date Field | Doc. No. | Party | Description |
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Jan 5, 2022 | 1 | petitioner | Petition for Inter Partes Review of U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1001 | petitioner | U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1002 | petitioner | Prosecution File History of U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1002 | petitioner | Prosecution File History of U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1002 | petitioner | Prosecution File History of U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1002 | petitioner | Prosecution File History of U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1003 | petitioner | Declaration of Henry Morrice Furneaux In Support of Petition for Inter Partes Review of U.S. Patent No. 10,900,034 Download |
Jan 5, 2022 | 1004 | petitioner | Curriculum Vitae of Dr. Henry Morrice Furneaux Download |
Jan 5, 2022 | 1005 | petitioner | Ayal Hendel et al., Chemically Modified Guide RNAs Enhance CRISPR-Cas Genome Edition in Human Primary Cells, 33 Nature Biotechnology, 985-989 (2015) Download |
Jan 5, 2022 | 1006 | petitioner | WO 2015/026885 A1 Download |
Jan 5, 2022 | 1007 | petitioner | Glen F. Deleavey & Masad J. Damha, Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing, 19 Chemistry & Biology, 937-954 (2012) Download |
Jan 5, 2022 | 1008 | petitioner | Jennifer A. Doudna and Emmanuelle Charpentier et al., Genome Editing. The New Frontier Of Genome Engineering with CRISPR-Cas9, 346 Science 6213, 1258096-1 - 1258096-9 (2014) Download |
Jan 5, 2022 | 1009 | petitioner | Jan Krutzfeldt et al., Specificity, Duplex Degradation and Subcellular Localization of Antagomirs, 35 Nucleic Acids Research, 2885-2892 (2007) Download |
Jan 5, 2022 | 1010 | petitioner | Richard N. Threlfall et al., Synthesis of Biological Activity of Phosphonoacetate- and Thiophosphonoacetate-Modified 2'-O-Methyl Oligoribonucleotides, 10 Organic & Biomolecular Chem., 746-754 (2012) Download |
Jan 5, 2022 | 1011 | petitioner | Byong Hoon Yoo et al., 2'-O-methyl Modified Phosphorothioate Antisense Oligonucleotides have Reduced Non-Specific Effects In Vitro, 32 Nucleic Acids Research, 2008-2016 (2004) Download |
Jan 5, 2022 | 1012 | petitioner | Jurgen Soutschek et. al., Therapeutic Silencing of an Endogenous Gene by Systemic Administration of Modified siRNAs, 432 Nature, 173-178 (2004) Download |
Jan 5, 2022 | 1013 | petitioner | Patrick D Hsu et al., DNA Targeting Specificity of RNA-guided Cas9 Nucleases, 31 Nature Biotechnology 827-832 (2013) Download |
Jan 5, 2022 | 1014 | petitioner | Mitchell O'Connell et al., Programmable RNA Recognition and Cleavage by CRISPR-Cas9, 516 Nature, 263-266 (2014) Download |
Jan 5, 2022 | 1015 | petitioner | GE Edit-R Flyer, gelifesciences.com/dharmacon Download |
Jan 5, 2022 | 1016 | petitioner | Sojung Kim et al., Highly Efficient RNA-guided Genome Editing in Human Cells Via Delivery of Purified Cas9 ribonucleoproteins, 24 Genome Research, 1012-1019 (2014) Download |
Jan 5, 2022 | 1017 | petitioner | Ophir Shalem et al., Genome-Scale CRISPR-Cas9 Knockout, 343 Science, 84-87 (2014) Download |
Jan 5, 2022 | 1018 | petitioner | Tim Wang et al., Genetic Screens in Human Cells Using the CRISPR-Cas9 System, 343 Science, 80-84 (2014) Download |
Jan 5, 2022 | 1019 | petitioner | U.S. Patent Pub. No. 2017/0166893 A1 (Doudna et al.) Download |
Jan 5, 2022 | 1020 | petitioner | U.S. Patent Pub. No. 2015/0232881 A1 (Glucksmann et al.) Download |
Jan 5, 2022 | 1021 | petitioner | U.S. Patent No. 9,885,033 ("Joung") Download |
Jan 5, 2022 | 1022 | petitioner | U.S. Patent Pub. No. 2015/0071889 A1 (Musunuru et al.) Download |
Jan 5, 2022 | 1023 | petitioner | EP 3835419 A1 (Doudna et al.) Download |
Jan 5, 2022 | 1024 | petitioner | Kim A. Lennox and Mark A. Behlke, A Direct Comparison of Anti-microRNA Oligonucleotide Potency, 27 Pharm Res., 1788-1799 (2010) Download |
Jan 5, 2022 | 1025 | petitioner | Fritz Eckstein, Phosphorothioates, Essential Components of Therapeutic Oligonucleotides, 24 Nucleic Acid Therapeutics, 374-387 (2014) Download |
Jan 5, 2022 | 1026 | petitioner | Hiroshi Nishimasu et al., Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA, 156 Cell, 935 (2014) Download |
Jan 5, 2022 | 1027 | petitioner | John Timmer, "Bacterial Immune System used to Engineer Human DNA in Human Cells," https://arstechnica.com/science/2013/01/bacterial-immune-system-used-to-engineer-human-dna-in-human-cells/ Download |
Jan 5, 2022 | 1028 | petitioner | Anne Trafton, "New Method for Turning Genes On and Off Could Enable More Complex Synthetic Biology Circuits," https://news.mit.edu/2013/an-easier-way-to-control-genes-0903 Download |
Jan 5, 2022 | 1029 | petitioner | Matthew Herper, "[CRISPR/Cas9] Is Spreading Like Wildfire from Everyone Who Knows About It and It Certainly is Very Tantalizing," https://www.forbes.com/sites/matthewherper/2013/03/19/the-protein-that-could-change-biotech-forever/?sh=15f215a32063 Download |
Jan 5, 2022 | 1030 | petitioner | Jan Krutzfeldt et al., Silencing of microRNAs in vivo with 'antagomirs', 438 Nature, 685-689 (2005) Download |
Jan 5, 2022 | 1031 | petitioner | WO 2008/091703 A2 (Stoffel et al.) Download |
Jan 5, 2022 | 1032 | petitioner | Bret P. Monia et al., Evaluation of 2'-modified Oligonucleotides Containing 2'-deoxy Gaps as Antisense Inhibitors of Gene Expression, 268 J. Biol. Chem., 14514 (1993) Download |
Jan 5, 2022 | 1033 | petitioner | Yanfang Fu et al., Improving CRISPR-Cas Nuclease Specificity Using Truncated Guide RNAs, 32 Nat Biotechnology, 279-284 (2014) Download |
Jan 5, 2022 | 1034 | petitioner | Wenyan Jiang et al., RNA-guided Editing of Bacterial Genomes Using CRISPR-Cas Systems, 31 Nat Biotechnology, 233-239 (2013) Download |
Jan 5, 2022 | 1035 | petitioner | Martin Jinek et al., A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity, 337 Science, 816-821 (2012) Download |
Jan 5, 2022 | 1036 | petitioner | Neville Sanjana et al., Improved Vectors and Genome-wide Libraries for CRISPR Screening, 11 Nature Methods, 783-784 (2014) Download |
Jan 5, 2022 | 1037 | petitioner | Hiroko Koike-Yusa et al., Genome-wide Recessive Genetic Screening in Mammalian Cells with a Lentiviral CRISPR-Guide RNA Library, 32 Nat Biotechnology, 267-273 (2014) Download |
Jan 5, 2022 | 1038 | petitioner | Yuexin Zhou et al., High-throughput Screening of a CRISPR/Cas9 Library for Functional Genomics in Human Cells, 509 Nature, 487-491 (2014) Download |
Jan 5, 2022 | 1039 | petitioner | Luke A. Gilbert et al., Genome-scale CRISPR-mediated control of gene repression and activation, 159 Cell, 647-661 (2014) Download |
Jan 5, 2022 | 1040 | petitioner | WO 2015/200555 (May) Download |
Jan 5, 2022 | 2 | petitioner | Petitioner Synthego Corporation's Power of Attorney Download |
Jan 12, 2022 | 3 | board | NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE Download |
Jan 26, 2022 | 4 | patent_own | Patent Owner's Mandatory Notice Download |
Jan 26, 2022 | 5 | patent_own | Patent Owner's Power of Attorney Download |
Mar 31, 2022 | 3001 | board | Exhibit 3001 Download |
Mar 31, 2022 | 6 | board | Order: Conduct of Proceeding 37 C.F.R. sec. 42.5 Download |
Apr 26, 2022 | 2003 | patent_own | EX2003 Download |
Apr 26, 2022 | 2004 | patent_own | EX2004 Download |
Apr 26, 2022 | 2005 | patent_own | EX2005 Download |
Apr 26, 2022 | 2006 | patent_own | EX2006 Download |
Apr 26, 2022 | 2007 | patent_own | EX2007 (Part 2/3) Download |
Apr 26, 2022 | 2007 | patent_own | EX2007 (Part 3/3) Download |
Apr 26, 2022 | 2007 | patent_own | EX2007 (Part 1/3) Download |
Apr 26, 2022 | 2008 | patent_own | EX2008 Download |
Apr 26, 2022 | 2009 | patent_own | EX2009 Download |
Apr 26, 2022 | 2010 | patent_own | EX2010 Download |
Apr 26, 2022 | 2011 | patent_own | EX2011 Download |
Apr 26, 2022 | 2012 | patent_own | EX2012 Download |
Apr 26, 2022 | 2013 | patent_own | EX2013 Download |
Apr 26, 2022 | 2014 | patent_own | EX2014 Download |
Apr 26, 2022 | 2015 | patent_own | EX2015 Download |
Apr 26, 2022 | 2016 | patent_own | EX2016 Download |
Apr 26, 2022 | 2017 | patent_own | EX2017 Download |
Apr 26, 2022 | 2019 | patent_own | EX2019 Download |
Apr 26, 2022 | 7 | patent_own | Patent Owner's Preliminary Response Download |
May 12, 2022 | 1041 | petitioner | Patent Scheduling Order in 5:21-cv-07801-EJD Download |
May 12, 2022 | 1042 | petitioner | LexMachina Time to Trial, Judge Davila Lifetime Download |
May 12, 2022 | 8 | petitioner | Petitioner's Reply to Patent Owner's Preliminary Response Download |
May 18, 2022 | 9 | patent_own | Patent Owner's Updated Mandatory Notice Download |
May 19, 2022 | 10 | patent_own | Patent Owner's Sur-Reply Download |
May 19, 2022 | 2011 | patent_own | EX2011 Download |
May 19, 2022 | 2013 | patent_own | EX2013 Download |
May 19, 2022 | 2018 | patent_own | EX2018 Download |
May 19, 2022 | 2020 | patent_own | EX2020 Download |
May 31, 2022 | 12 | board | Institution Decision Granting Institution of Inter Partes Review Download |
May 31, 2022 | 13 | board | Scheduling Order Download |
Jun 14, 2022 | 14 | patent_own | Patent Owner's Objections to Evidence Download |
Jul 25, 2022 | 15 | patent_own | Joint Scheduling Stipulation Regarding Due Dates 1-3 Download |
Aug 29, 2022 | 16 | patent_own | Patent Owner's Notice of Deposition of Henry Morrice Furneaux Download |
Sep 20, 2022 | 2021 | patent_own | EX2021 Download |
Sep 20, 2022 | 2023 | patent_own | EX2023 Download |
Sep 20, 2022 | 2024 | patent_own | EX2024 Download |
Sep 20, 2022 | 2025 | patent_own | EX2025 Download |
Sep 20, 2022 | 2026 | patent_own | EX2026 Download |
Sep 20, 2022 | 2027 | patent_own | EX2027 Download |
Sep 20, 2022 | 2028 | patent_own | EX2028 Download |
Sep 20, 2022 | 2029 | patent_own | EX2029 Download |
Sep 20, 2022 | 2030 | patent_own | EX2030 Download |
Sep 20, 2022 | 2031 | patent_own | EX2031 Download |
Sep 20, 2022 | 2032 | patent_own | EX2032 Download |
Sep 20, 2022 | 2033 | patent_own | EX2033 Download |
Sep 20, 2022 | 2034 | patent_own | EX2034 Download |
Sep 20, 2022 | 2035 | patent_own | EX2035 Download |
Sep 20, 2022 | 2036 | patent_own | EX2036 Download |
Sep 20, 2022 | 2037 | patent_own | EX2037 Download |
Sep 20, 2022 | 2038 | patent_own | EX2038 Download |
Sep 20, 2022 | 2039 | patent_own | EX2039 Download |
Sep 20, 2022 | 2040 | patent_own | EX2040 Download |
Sep 20, 2022 | 2041 | patent_own | EX2041 Download |
Sep 20, 2022 | 2042 | patent_own | EX2042 Download |
Sep 20, 2022 | 2043 | patent_own | EX2043 Download |
Sep 20, 2022 | 2044 | patent_own | EX2044 Download |
Sep 20, 2022 | 2045 | patent_own | EX2045 Download |
Sep 20, 2022 | 2046 | patent_own | EX2046 Download |
Sep 20, 2022 | 2047 | patent_own | EX2047 Download |
Sep 20, 2022 | 2048 | patent_own | EX2048 Download |
Sep 20, 2022 | 2049 | patent_own | EX2049 Download |
Sep 20, 2022 | 2050 | patent_own | EX2050 Download |
Sep 20, 2022 | 2051 | patent_own | EX2051 Download |
Sep 20, 2022 | 2052 | patent_own | EX2052 Download |
Sep 20, 2022 | 2053 | patent_own | EX2053 Download |
Sep 20, 2022 | 2054 | patent_own | EX2054 Download |
Sep 20, 2022 | 2055 | patent_own | EX2055 Download |
Sep 20, 2022 | 2056 | patent_own | EX2056 Download |
Sep 20, 2022 | 2057 | patent_own | EX2057 Download |
Sep 20, 2022 | 2058 | patent_own | EX2058 Download |
Sep 20, 2022 | 2059 | patent_own | EX2059 Download |
Sep 20, 2022 | 2060 | patent_own | EX2060 Download |
Sep 20, 2022 | 2061 | patent_own | EX2061 Download |
Sep 20, 2022 | 2062 | patent_own | EX2062 Download |
Sep 21, 2022 | 17 | patent_own | Patent Owner Response Download |
Sep 21, 2022 | 18 | patent_own | Patent Owner's Corrected Response Download |
Sep 21, 2022 | 2063 | patent_own | EX2063 Download |
Sep 27, 2022 | 19 | petitioner | Petitioner's Evidentiary Objections to Exhibits Filed with Patent Owner's Response Download |
Oct 7, 2022 | 20 | patent_own | PATENT OWNER'S UNOPPOSED MOTION FOR PRO HAC VICE ADMISSION OF DENISE DE MORY Download |
Oct 7, 2022 | 2001 | patent_own | EX2001 Download |
Oct 14, 2022 | 21 | board | Order: on Motion Download |
Nov 7, 2022 | 22 | petitioner | Petitioner Synthego Corporation's Notice of Deposition of Dr. Jeffrey R. Sampson Download |
Nov 9, 2022 | 1043 | petitioner | Ex. 1043 - Reines Decl ISO PHV Mtn Download |
Nov 9, 2022 | 1044 | petitioner | Ex. 1044 - In Re Reines, 14-MA004 (14-4) (Fed. Cir. 2014-11-05) Download |
Nov 9, 2022 | 1045 | petitioner | Ex. 1045 - Reines Personal Statement (Fed. Cir. 14-4) (421) Download |
Nov 9, 2022 | 23 | petitioner | Petitioner Synthego Corporation's Motion for Admission Pro Hac Vice of Edward R. Reines Pursuant to 37 C.F.R. Section 42.10 Download |
Nov 9, 2022 | 24 | petitioner | Petitioner Synthego Corporation's Updated Exhibit List Download |
Nov 18, 2022 | 25 | petitioner | Petitioner Synthego Corporation's Notice of Deposition of Dr. William S. Marshall Download |
Nov 21, 2022 | 26 | board | ORDER Conditionally Granting Petitioners Unopposed Motions for Pro Hac Vice Admission of Edward R. Reines 37 C.F.R. sec 42.10 Download |
Nov 23, 2022 | 27 | petitioner | Petitioner Synthego Corporation's Supplemental Power of Attorney for Edward R. Reines Download |
Nov 23, 2022 | 28 | petitioner | Petitioner Synthego Corporation's Supplemental Mandatory Notice Adding Backup Counsel Under 37 C.F.R. Section 42(a)(3) Download |
Dec 13, 2022 | 1047 | petitioner | EX1047 Download |
Dec 13, 2022 | 1048 | petitioner | EX1048 Download |
Dec 13, 2022 | 1049 | petitioner | EX1049 Download |
Dec 13, 2022 | 1050 | petitioner | EX1050 Download |
Dec 13, 2022 | 1051 | petitioner | EX1051 Download |
Dec 13, 2022 | 1052 | petitioner | EX1052 Download |
Dec 13, 2022 | 1053 | petitioner | EX1053 - Redacted Version Download |
Dec 13, 2022 | 1054 | petitioner | EX1054 - Redacted Version Download |
Dec 13, 2022 | 1055 | petitioner | EX1055 - Redacted Version Download |
Dec 13, 2022 | 1056 | petitioner | EX1056 - Redacted Version Download |
Dec 13, 2022 | 1057 | petitioner | EX1057 - Redacted Version Download |
Dec 13, 2022 | 1058 | petitioner | EX1058 - Redacted Version Download |
Dec 13, 2022 | 1059 | petitioner | EX1059 Download |
Dec 13, 2022 | 1060 | petitioner | EX1060 Download |
Dec 13, 2022 | 1061 | petitioner | EX1061 Download |
Dec 13, 2022 | 1062 | petitioner | EX1062 Download |
Dec 13, 2022 | 29 | petitioner | Joint Motion to Seal Download |
Dec 13, 2022 | 31 | petitioner | Petitioner's Reply to Patent Owner's Response - Redacted Version Download |
Jan 14, 2023 | 34 | patent_own | Motion to Seal Portions of Patent Owner's Sur-Reply Brief Download |
Jan 14, 2023 | 35 | patent_own | Patent Owner's Sur-Reply [Redacted Version] Download |
Jan 17, 2023 | 37 | patent_own | Patent Owner's Request for Oral Argument Download |
Jan 17, 2023 | 36 | petitioner | Petitioner Synthego Corporation's Request for Oral Argument Pursuant to 37 C.F.R. Section 42.70(a) Download |
Jan 24, 2023 | 38 | board | Download |
Feb 2, 2023 | 39 | petitioner | Download |
Feb 2, 2023 | 40 | board | Order: Setting Oral Argument Download |
Feb 8, 2023 | 41 | petitioner | Joint Stipulation Regarding Service of Demonstratives Download |
Feb 20, 2023 | 42 | patent_own | Updated Power of Attorney Download |
Feb 20, 2023 | 43 | patent_own | Updated Mandatory Notice Download |
Feb 21, 2023 | 44 | patent_own | Joint Stipulation Regarding Service of Demonstratives Download |
Feb 24, 2023 | 45 | petitioner | Download |
Feb 24, 2023 | 46 | patent_own | Agilent Technologies Inc.'s Oral Argument Presentation Download |
Mar 13, 2023 | 47 | board | Other: Hearing transcript Download |
Mar 14, 2023 | 48 | board | Other: Hearing transcript Download |
May 17, 2023 | 49 | board | Final Written Decision Download |
Jul 17, 2023 | 50 | patent_own | Patent Owner's Notice of Appeal Download |
Jul 17, 2023 | 51 | patent_own | Proof of Service for Notice of Appeal Download |