Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues | Patent Publication Number 20020127590
US 20020127590 A1Patent NumberUS 06924108 B2
Application Number10080767
Filled DateFeb 22, 2002
Priority DateDec 21, 1999
Publication DateSep 12, 2002
Original AssigneeIngenium Patents
Current AssigneeIngenium Patents
Inventor/ApplicantsJasmine I. Daksis
Glen H. Erikson
Jasmine I. Daksis
Glen H. Erikson
Glen H. Erikson
Jasmine I. Daksis
Glen H. Erikson
International
1
C12Q
National
5
435/6
536/23.1
536/24.32
536/24.33
435/600.
Field of Search
0
- 1. In a method of forming a complex between a probe containing probe nucleobases and a target containing target nucleobases, comprising mixing said probe and said target under hybridizing conditions, the improvement wherein at least one blocking agent comprising at least one nucleobase is conjugated to said probe and/or said target prior to hybridizing said probe with said target, wherein said conjugation enhances an avidity and/or a specificity of said hybridizing.
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