Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) | Patent Publication Number 20030232873
US 20030232873 A1Patent NumberUS 07122570 B2
Application Number10319833
Filled DateDec 16, 2002
Priority DateDec 21, 2001
Publication DateDec 18, 2003
Original AssigneeZentaris Ag
Current AssigneeBlitz F02570 Gmbh
Inventor/ApplicantsMarcus Karl Koppitz
Hans Peter Muhn
Holger Hess-Stump
Klaus Wolfgang Paulini
Kenneth Jay Shaw
Klaus Paulini
Marcus Karl Koppitz
Holger Hess-Stumpp
Hans Peter Muhn
Kenneth Jay Shaw
Hans Peter Muhn
Holger Hess-Stump
Klaus Wolfgang Paulini
Kenneth Jay Shaw
Klaus Paulini
Marcus Karl Koppitz
Holger Hess-Stumpp
Hans Peter Muhn
Kenneth Jay Shaw
International
2
C07D
A61K
National
7
548/444.
514/411.
546/276.7
514/411
548/448
548/439
514/339
Field of Search
0
- 1. Compound of general formula (I)
- 4. Compound according to one of claims 1 to 3, whereby radicals R2, R3, R4 and/or R5 are not hydrogen atoms.
- 7. Compound according to one of claims 1 to 5, whereby radical R6 is a hydrophobic radical that comprises alkyl, aryl and/or hetaryl structures and that carries a hydrogen bridge-donor-acceptor system at a distance of two to four single bonds, counting from the carbon atoms that are substituted by radicals R6 and R7.
- 10. Compound according to one of claims 1 to 5, 7 or 8, whereby radical R is a hydrophobic radical that comprises alkyl, aryl and/or hetaryl structures.
- 13. Compound according to one of claims 1 to 5, 7, 8, 10 or 11, whereby the compound is present on the carbon atom in R-configuration that is substituted by radicals R6 and R7, if radicals R6 and R7 together form an alpha-aminocarboxylic acid structural element.
- 15. Pharmaceutical composition that comprises at least one compound according to one of claims 1 to 14.
- 18. Process for the production of a compound according to one of claims 1 to 14.
- 19. Compound according to one of claims 1 to 14, for use as a pharmaceutical agent.
- 20. Use of a compound according to one of claims 1 to 14, for the production of a pharmaceutical agent for treating pathologic conditions that are mediated by G-protein-coupled receptors.
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