Date Field | Doc. No. | Party | Description |
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Aug 21, 2023 | 25 | board | Download |
Aug 16, 2023 | 23 | petitioner | Joint Motion To Terminate Proceedings Download |
Aug 16, 2023 | 24 | petitioner | Joint Request To Treat Settlement Agreement As Business Confidential Information And To Keep Separate Download |
Aug 16, 2023 | 3001 | board | Exhibit 3001 Download |
Aug 3, 2023 | 22 | board | Order Download |
Jul 21, 2023 | 20 | patent_own | Download |
Jul 21, 2023 | 2054 | patent_own | DECLARATION OF JEREMIAH W. NIXON IN SUPPORT OF MOTION FOR ADMISSION PRO HAC VICE Download |
Jul 21, 2023 | 21 | patent_own | Patent Owner's Updated Exhibit List Download |
Jul 21, 2023 | 19 | patent_own | PHV Motion Download |
Jul 17, 2023 | 18 | petitioner | Petitioner's Notice of Deposition Of Dr. C. Kathleen Dorey Download |
Jul 14, 2023 | 17 | petitioner | Joint Notice Of Stipulation To Change Due Dates Download |
Jun 26, 2023 | 14 | petitioner | PHV Motion for S Kline Download |
Jun 26, 2023 | 15 | petitioner | PHV Motion for M Chou Download |
Jun 23, 2023 | 1050 | petitioner | Declaration of S Kline Download |
Jun 23, 2023 | 1051 | petitioner | Declaration of M Chou Download |
Jun 23, 2023 | 12 | petitioner | Petitioner's Updated Mandatory Notice Download |
Jun 23, 2023 | 13 | petitioner | Petitioner's Updated Exhibit List Download |
Jun 23, 2023 | 0 | petitioner | PHV Motion for S Kline Download |
May 8, 2023 | 11 | board | Order: Panel Change Order Download |
May 5, 2023 | 10 | patent_own | Download |
May 5, 2023 | 2018 | patent_own | Download |
May 5, 2023 | 2019 | patent_own | Supplemental Declaration of Dr. C. Kathleen Dorey, Ph. D. Download |
May 5, 2023 | 2021 | patent_own | Appeal 2013-000129 for Application 10/746,403 Download |
May 5, 2023 | 2022 | patent_own | Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996 Download |
May 5, 2023 | 2023 | patent_own | Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD, Menendez E, Vidal I, Wang W (1997) Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res 64, 211-218 Download |
May 5, 2023 | 2024 | patent_own | Bone RA, Landrum JT, Hime GW, Cains A, Zamor J (1993) Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci 34, 2033-2040 Download |
May 5, 2023 | 2025 | patent_own | Shyam R, Gorusupudi A, Nelson K, Horvath MP, Bernstein PS (2017) RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc Natl Acad Sci U S A 114, 10882-10887 Download |
May 5, 2023 | 2026 | patent_own | Arunkumar R, Gorusupudi A, Bernstein PS (2020) The macular carotenoids: A biochemical overview. Biochim Biophys Acta Mol Cell Biol Lipids 1865, 158617 Download |
May 5, 2023 | 2027 | patent_own | Mares J (2016) Lutein and Zeaxanthin Isomers in Eye Health and Disease. Annu Rev Nutr 36, 571-602 Download |
May 5, 2023 | 2028 | patent_own | Nolan JM, Beatty S, Meagher KA, Howard AN, Kelly D, Thurnham DI (2014) Verification of Meso-Zeaxanthin in Fish. J Food Process Technol 5, 335 Download |
May 5, 2023 | 2029 | patent_own | Nolan JM, Beatty S, Meagher KA, Howard AN, Kelly D, Thurnham DI (2014) Verification of Meso-Zeaxanthin in Fish. J Food Process Technol 5, 335 Download |
May 5, 2023 | 2030 | patent_own | Everts S (2013) Mirror molecules. Sci Am 308, 78-81. Download |
May 5, 2023 | 2031 | patent_own | Avetisov V, Goldanskii V (1996) Mirror symmetry breaking at the molecular level. Proc Natl Acad Sci U S A 93, 11435-11442 Download |
May 5, 2023 | 2032 | patent_own | Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000) Vitamin E In Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academies Press (US);, Washington DC. Download |
May 5, 2023 | 2033 | patent_own | Office of Dietary Supplements, Vitamin E. Fact sheet for health professionals, National Institutes of Health, https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/, March 26, 2021, Accessed 1/22/2023. Download |
May 5, 2023 | 2034 | patent_own | Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74, 714-722. Download |
May 5, 2023 | 2035 | patent_own | Di Mambro VM, Azzolini AE, Valim YM, Fonseca MJ (2003) Comparison of antioxidant activities of tocopherols alone and in pharmaceutical formulations. Int J Pharm 262, 93-99 Download |
May 5, 2023 | 2036 | patent_own | Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 20, 689-709 Download |
May 5, 2023 | 2037 | patent_own | Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, et al. (2020) Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases Front Physiol 11, 694 Download |
May 5, 2023 | 2038 | patent_own | Crabtree DV, Adler AJ, Snodderly DM (1996) Radial distribution of tocopherols in rhesus monkey retina and retinal pigment epithelium-choroid. Invest Ophthalmol Vis Sci 37, 61-76 Download |
May 5, 2023 | 2039 | patent_own | Yeum KJ, Taylor A, Tang G, Russell RM (1995) Measurement of carotenoids, retinoids, and tocopherols in human lenses. Invest Ophthalmol Vis Sci 36, 2756-2761 Download |
May 5, 2023 | 2040 | patent_own | Bieri JG, Evarts RP (1974) Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition. Am J Clin Nutr 27, 980-986 Download |
May 5, 2023 | 2041 | patent_own | Giovannucci E (2000) Gamma-tocopherol: a new player in prostate cancer prevention? J Natl Cancer Inst 92, 1966-1967 Download |
May 5, 2023 | 2042 | patent_own | Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP, Morris JS, Comstock GW (2000) Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst 92, 2018-2023 Download |
May 5, 2023 | 2043 | patent_own | Age-Related Eye Disease Study Research G (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol 119, 1439-1452 Download |
May 5, 2023 | 2044 | patent_own | Rozanowska M, Edge R, Land EJ, Navaratnam S, Sarna T, Truscott TG (2019) Scavenging of retinoid cation radicals by urate, Trolox, and alpha-, beta-, gamma-, and delta-tocopherols. Int J Mol Sci 20 Download |
May 5, 2023 | 2045 | patent_own | Reme CE, Malnoe A, Jung HH, Wei Q, Munz K (1994) Effect of dietary fish oil on acute light- induced photoreceptor damage in the rat retina. Invest Ophthalmol Vis Sci 35, 78-90 Download |
May 5, 2023 | 2046 | patent_own | Thomson LR, Toyoda Y, Delori FC, Garnett KM, Wong ZY, Nichols CR, Cheng KM, Craft NE, Dorey CK (2002) Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail. Exp Eye Res 75, 529-542 Download |
May 5, 2023 | 2047 | patent_own | Trevithick-Sutton CC, Foote CS, Collins M, Trevithick JR (2006) The retinal carotenoids zeaxanthin and lutein scavenge superoxide and hydroxyl radicals: a chemiluminescence and ESR study. Mol Vis 12, 1127-1135. Download |
May 5, 2023 | 2048 | patent_own | Aonuma H, Koide K, Masuda K, Watanabe I (1997) Retinal light damage: protective effect of alpha-tocopherol. Jpn J Ophthalmol 41, 160-167 Download |
May 5, 2023 | 2049 | patent_own | Christen S, Woodall AA, Shigenaga MK, Southwell-Keely PT, Duncan MW, Ames BN (1997) gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha- tocopherol: physiological implications. Proc Natl Acad Sci U S A 94, 3217-3222 Download |
May 5, 2023 | 2050 | patent_own | Liu M, Wallin R, Wallmon A, Saldeen T (2002) Mixed tocopherols have a stronger inhibitory effect on lipid peroxidation than alpha-tocopherol alone. J Cardiovasc Pharmacol 39, 714-721 Download |
May 5, 2023 | 2051 | patent_own | Huang HY, Appel LJ (2003) Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans. J Nutr 133, 3137-3140 Download |
May 5, 2023 | 2052 | patent_own | Handelman GJ, Machlin LJ, Fitch K, Weiter JJ, Dratz EA (1985) Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. J Nutr 115, 807-813 Download |
May 5, 2023 | 2053 | patent_own | Morton LW, Ward NC, Croft KD, Puddey IB (2002) Evidence for the nitration of gamma- tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart disease. Biochem J 364, 625-628 Download |
Feb 14, 2023 | 9 | board | Order: SCHEDULING ORDER Download |
Feb 10, 2023 | 7 | board | Institution Decision: Grant Download |
Nov 18, 2022 | 2001 | patent_own | Declaration of Dr. C. Kathleen Dorey, Ph.D. Download |
Nov 18, 2022 | 2002 | patent_own | Handelman GJ (2001) The evolving role of carotenoids in human biochemistry Download |
Nov 18, 2022 | 2003 | patent_own | Sies H, Stahl W, Sundquist AR (1992) Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids Download |
Nov 18, 2022 | 2004 | patent_own | Tang G (2010) Bioconversion of dietary provitamin A carotenoids to vitamin A in humans. Download |
Nov 18, 2022 | 2005 | patent_own | Ala-Laurila P, Kolesnikov AV, Crouch RK, Tsina E, Shukolyukov SA, Govardovskii VI, Koutalos Y, Wiggert B, Estevez ME, Cornwall MC (2006) Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology Download |
Nov 18, 2022 | 2006 | patent_own | Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease Download |
Nov 18, 2022 | 2007 | patent_own | Leo, M.A. & Lieber, C.S. (1999) Alcohol, vitamin A, and beta-carotene: Adverse interactions, including hepatotoxicity and carcinogenicity Download |
Nov 18, 2022 | 2008 | patent_own | Albanes D, Virtamo J, Taylor PR, Rautalahti M, Pietinen P, Heinonen OP (1997) Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Download |
Nov 18, 2022 | 2009 | patent_own | The Alpha-Tocopherol BCCPSG (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers Download |
Nov 18, 2022 | 2010 | patent_own | Speizer FE, Colditz GA, Hunter DJ, Rosner B, Hennekens C (1999) Prospective study of smoking, antioxidant intake, and lung cancer in middle-aged women (USA) Download |
Nov 18, 2022 | 2011 | patent_own | Goodman GE, Schaffer S, Omenn GS, Chen C, King I (2003) The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial. Download |
Nov 18, 2022 | 2012 | patent_own | Mannisto S, Smith-Warner SA, Spiegelman D, Albanes D, Anderson K, van den Brandt PA, Cerhan JR, Colditz G, Feskanich D, Freudenheim JL, Giovannucci E, Goldbonhm RA, Graham S, Miller AB, Rohan TE, Virtamo J, Willett WC, Hunter DJ (2004) Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies Download |
Nov 18, 2022 | 2013 | patent_own | Bendich A, Olson JA (1989) Biological actions of carotenoids Download |
Nov 18, 2022 | 2014 | patent_own | Block G, Patterson B, Subar A (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence Download |
Nov 18, 2022 | 2015 | patent_own | Michaud DS, Feskanich D, Rimm EB, Colditz GA, Speizer FE, Willett WC, Giovannucci E (2000) Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. Download |
Nov 18, 2022 | 2016 | patent_own | Correspondence, Beta Carotene, Vitamin E, and Lung Cancer Download |
Nov 18, 2022 | 2017 | patent_own | Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Jr., Valanis B, Williams JH, Jr., Barnhart S, Cherniack MG, Brodkin CA, Hammar S (1996) Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. Download |
Nov 18, 2022 | 6 | patent_own | Patent Owner's Preliminary Response Download |
Sep 6, 2022 | 4 | patent_own | Patent Owner's Power of Attorney Download |
Sep 6, 2022 | 5 | patent_own | Patent Owner's Mandatory Notice Download |
Aug 26, 2022 | 3 | board | Notice: Notice filing date accorded Download |
Aug 19, 2022 | 1 | petitioner | Bausch's Power of Attorney Download |
Aug 19, 2022 | 1001 | petitioner | U.S. Patent No. 11,173,133 Download |
Aug 19, 2022 | 1002 | petitioner | File History for U.S. Patent No. 11,173,133 Download |
Aug 19, 2022 | 1003 | petitioner | File History for Provisional Application No. 60/453,522 Download |
Aug 19, 2022 | 1004 | petitioner | File History for Provisional Application No. 60/435,522 Download |
Aug 19, 2022 | 1005 | petitioner | Transaction History for Provisional Application No. 60/435,522 Download |
Aug 19, 2022 | 1006 | petitioner | Status of Provisional Application No. 60/435,522 Download |
Aug 19, 2022 | 1007 | petitioner | Excerpt of File History for U.S. Patent No. 9,192,586 Download |
Aug 19, 2022 | 1008 | petitioner | FAO, Tocopherol Concentrate, Mixed, U.N. (1986) Download |
Aug 19, 2022 | 1009 | petitioner | WO 2001/019383 (Lang) Download |
Aug 19, 2022 | 1010 | petitioner | U.S. Patent No. 6,582,721 Download |
Aug 19, 2022 | 1011 | petitioner | WO 2003/063848 (Barker) Download |
Aug 19, 2022 | 1012 | petitioner | U.S. Patent No. 5,747,544 (Garnett) Download |
Aug 19, 2022 | 1013 | petitioner | WO 2002/047493 Download |
Aug 19, 2022 | 1014 | petitioner | Nicholas A. Phelps Brown et al., Nutrition supplements and the eye, 12 EYE 127 (1998) (Brown) Download |
Aug 19, 2022 | 1015 | petitioner | D. Max Snodderly, Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins, 62(suppl) AM. J. CLIN. NUTR. 1448S (1995) Download |
Aug 19, 2022 | 1016 | petitioner | Takashi Maoka et al., The First Isolation of Enantiomeric and Meso-Zeaxanthin in Nature, 83B COMP. BIOCHEM. PHYSIOL. 121 (1986) Download |
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Aug 19, 2022 | 1021 | petitioner | Joachim Paust, Technical Syntheses, in 2 CAROTENOIDS 259 (George Britton et al. eds., 1996) Download |
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Aug 19, 2022 | 1023 | petitioner | FAO, Zeaxanthin: Chemical and Technical Assessment (CTA), U.N. (2004) Download |
Aug 19, 2022 | 1024 | petitioner | Declaration of Elizabeth J. Johnson, Ph.D. Download |
Aug 19, 2022 | 1027 | petitioner | Anita M. Van der Hagen, et al., Free Radicals and Antioxidant Supplementation: A Review of Their Roles in Age-Related Macular Degeneration, 64 J. AM. OPTOMETRIC ASS'N 871 (1993) Download |
Aug 19, 2022 | 1028 | petitioner | Download |
Aug 19, 2022 | 1029 | petitioner | Norman I. Krinsky, et al., Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye, 23 ANN. REV. NUTR. 171 (2003) Download |
Aug 19, 2022 | 1030 | petitioner | Thomas G. Guilliams, ed., Free Radicals, Antioxidants and Eye Diseases, 2 THE STANDARD (1999) Download |
Aug 19, 2022 | 1031 | petitioner | Download |
Aug 19, 2022 | 1032 | petitioner | AREDS Report No. 8, 119 ARCH OPHTHALMOLOGY 1417 (2001) Download |
Aug 19, 2022 | 1033 | petitioner | AREDS Report No. 9, 119 ARCH OPHTHALMOLOGY 1439 (2001) Download |
Aug 19, 2022 | 1034 | petitioner | Elizabeth J. Johnson, et al., Nutritional Manipulation of Primate Retinas, III: Effects of Lutein or Zeaxanthin Supplementation on Adipose Tissue and Retina of Xanthophyll-Free Monkeys, 46 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCI. 692 (2005) Download |
Aug 19, 2022 | 1037 | petitioner | Maggie B. Covington, Omega-3 Fatty Acids, 70 AMERICAN FAMILY PHYSICIAN 133 (2004) Download |
Aug 19, 2022 | 1038 | petitioner | Download |
Aug 19, 2022 | 1039 | petitioner | Fish Oil Monograph, 5 ALTERNATIVE MED. REVIEW 576 (2000) Download |
Aug 19, 2022 | 1041 | petitioner | ZeaVision, LLC v. Bausch & Lomb Inc., No. 4:21-cv-01352 (E.D. Mo.), D.I. 1 (Zeavision II) Download |
Aug 19, 2022 | 1042 | petitioner | U.S. Patent No. 9,192,586 Download |
Aug 19, 2022 | 1043 | petitioner | Lee M. Jampol, Antioxidants, zinc, and age-related macular degeneration, 119 ARCH OPHTHALMOLOGY, 1533 (2001) (Jampol) Download |
Aug 19, 2022 | 1044 | petitioner | Billy R. Hammond, et al., Cigarette smoking and retinal carotenoids: Implications for age-related macular degeneration, 36 VISION RESEARCH 3003 (1996) Download |
Aug 19, 2022 | 1045 | petitioner | Leslie Hyman & Rebecca Nebrosky, Risk factors for age-related macular degeneration: An update, 13 CURRENT OPINION OPHTHALMOLOGY 171 (2002) Download |
Aug 19, 2022 | 1046 | petitioner | Susan T. Mayne, Beta-carotene, carotenoids, and disease prevention in humans, 10 FASEB J 690 (1996) Download |
Aug 19, 2022 | 1047 | petitioner | Christopher W. Lievens, An update on AREDS, 140 REVIEW OF OPTOMETRY, 91 (2003) Download |
Aug 19, 2022 | 1048 | petitioner | Download |
Aug 19, 2022 | 1049 | petitioner | Download |
Aug 19, 2022 | 2 | petitioner | Petition for Inter Partes Review of U.S. Patent No. 11,173,133 Download |